pelargonidin improves passive avoidance task performance in a rat amyloid beta25-35 model of alzheimer’s disease via estrogen receptor independent pathways

Pelargonidin Improves Passive Avoidance Task Performance in a Rat Amyloid Beta25-35 Model of Alzheimer's Disease Via Estrogen Receptor Independent Pathways.

Alzheimer's disease (AD) is a disorder with multiple pathophysiological causes, destructive outcomes, and no available definitive cure. Pelargonidin (Pel), an anthocyanin derivative, is an estrogen receptor agonist with little estrogen side effects. This study was designed to assess Pel memory enhancing effects on the a rat Amyloid Beta25-35 (Aβ) intrahippocampal microinjections model of AD in ...

Mespilus germanica leaves flavonoids improve passive avoidance memory and apoptosis in a rat model of amyloid-β neurotoxicity

Introduction: Alzheimer’s disease (AD) is a common progressive, neurodegenerative disorder with no preventive or curative therapy until now. Use of natural products as an important source of neuroprotective flavonoids against AD has been considered recently. In this study, the effect of Mespilus germanica leaves (MGL) flavonoids treatment on memory dysfunction and apoptosis in the amyloid beta ...

Varenicline Ameliorates Learning and Memory Deficits in Amyloid β(25–35) Rat Model of Alzheimer’s Disease

Introduction: Alzheimer’s disease (AD) is a enfeeble neurodegenerative disorder characterized by increased β-amyloid (Aβ) deposition and neuronal dysfunction leading to impaired learning and recall. Among proposed risk factors, impaired cholinergic transmission is a main cause for incidence of disease. Methods: In the present study, effects of the intracerebroventricularly administration of an ...

Rosmarinic acid mitigates learning and memory disturbances in amyloid β(25–35)-induced model of Alzheimer’s disease in rat

Abstract Background and Objective: Alzheimer’s disease (AD) is a weakening neurodegenerative disorder typified by increased b-amyloid (Ab) deposition and neuronal dysfunction causing to impaired learning and memory. Among proposed risk factors, induced oxidative stress is a main cause for incidence of the disease. The aim of this study was to determine the effects of the rosmarinic acid on lear...

CX691 as an AMPA receptor positive modulator, improves the learning and memory in a rat model of Alzheimer’s disease

Objective(s): Growing evidence suggests that dysfunction of the glutamatergic system and α-amino-3-hydroxy-5-methyl-4-isoazolepropionic acid (AMPA) receptors are involved in pathology of Alzheimer’s disease (AD). Because AMPA receptors play a key role in plasticity synaptic regulation, positive modulation of these receptors may rescue the cognitive deficits in the AD. The aim of this study was ...

the effect of pre-training infusions of estrogen receptor ligands in the ca1 region of hippocampus on passive avoidance task